DSIP (delta sleep inducing peptide or delta sleep peptide) was first discovered in 1974 by the Swiss G. Schoeneberger and M. Monnier, who isolated it from the brain blood of sleeping rabbits. Since the discovery, several hundred articles have been published, most of which describe the localization and involvement of the peptide in the brain and peripheral nervous system.
The main property of DSIP is the ability to induce a stage of non-REM sleep, which is effective in combating insomnia. The peptide was found to affect electrophysiological activity, neurotransmitter levels in the brain, circadian and locomotor structures, hormonal levels, psychological performance and concentration, and the activity of neuropharmacological drugs.
A pronounced effect on withdrawal symptoms, including pain conditions in alcoholics and drug addicts, was noted. It has also been shown to be effective in chronic pain, including migraines.
Basic Info. Retatrutide is an experimental drug developed by Eli Lilly and Company in the United States for the treatment of obesity. It is a triple glucagon hormone receptor agonist. In a phase II clinical trial, the drug has been proved to reduce the average weight of non diabetes but obese or pre obese (overweight) adults by more than 17.5% ...
Basic Info. Kisspeptin-10 is a decapeptide that plays a crucial role in the hypothalamic-pituitary-gonadal axis, stimulating the release of gonadotropins and, consequently, reproductive hormones. It is also known to have vasoactive properties , inhibiting angiogenesis and acting as a tumor metastasis suppress or. The studies indicate that kisspeptin-10 significantly increases the content of intracellular collagen in the myocardium. KiSS-10 also elevates the level of phosphorylated focal adhesion The inhibition of FAK negates the stimulatory effect of KiSS-10 on collagen deposition in vitro. ...
Basic Info. Tirzepatide is a revolutionary medication used primarily for managing weight and blood sugar levels. It works by mimicking two naturally occurring hormones in your body: GLP-1 and GIP. These hormones help regulate your appetite, control your blood sugar levels, and promote weight loss by making you feel full faster and for longer periods . ...
Basic Info. Tesamorelin is the N -terminally modified compound based on 44 amino acids sequence of human GHRH. This modified synthetic form is more potent and stable than the natural peptide. It is also more resistant to cleavage by the dipetidy aminopeptidase than human GHRH. It stimulates the synthesis and release of endogenous GH, with an increase in level of insulin-like growth factor . The released GH then binds with the receptors present on various body organs and regulates the body composition. This regulation is mainly because of the combination of anabolic and lipolytic mechanisms. However, it has been found that the main mechanisms by which Tesamorelin reduces body fat mass are lipolysis followed by reduction in triglycerides level. ...
Basic Info. Des(1-3)IGF-1 is a naturally occurring, endogenous protein, as well as drug, and truncated analogue of insulin-like growth factor 1 (IGF-1).des(1-3)IGF-1 lacks the first three amino acids at the N-terminus of IGF-1 (for a total of 67 amino acids, relative to the 70 of IGF-1). As a result of this difference, it has considerably reduced binding to the insulin-like growth factor-binding proteins (IGFBPs) and enhanced potency (about 10-fold in vivo) relative to IGF-1. ...
